Eckart Fleck Selected Research

tetrapeptide carbamate

11/2005	Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels.
5/2005	Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
4/2005	Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
2/2004	Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling.
3/2003	Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Eckart Fleck Research Topics

Disease

19	Coronary Artery Disease (Coronary Atherosclerosis) 05/2015 - 01/2002
15	Atherosclerosis 01/2013 - 02/2002
8	Heart Failure 08/2013 - 03/2002
8	Body Weight (Weight, Body) 02/2012 - 01/2003
5	Hypertension (High Blood Pressure) 08/2018 - 10/2010
5	Myocardial Ischemia (Ischemic Heart Diseases) 06/2014 - 01/2002
5	Myocardial Infarction 01/2014 - 02/2004
5	Inflammation (Inflammations) 06/2013 - 01/2008
4	Fibrosis (Cirrhosis) 12/2014 - 07/2005
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2014 - 01/2008
4	Atherosclerotic Plaque (Atheroma) 02/2012 - 02/2004
4	Coronary Stenosis (Coronary Artery Stenosis) 01/2011 - 01/2005
4	Pathologic Constriction (Stenosis) 01/2011 - 01/2006
4	Vascular Diseases (Vascular Disease) 12/2004 - 05/2002
3	Atrial Fibrillation 01/2015 - 01/2009
3	Death (Near-Death Experience) 01/2014 - 02/2004
3	Cicatrix (Scar) 08/2013 - 05/2004
3	Neointima 02/2013 - 03/2003
3	Obesity 01/2013 - 11/2002
3	Heart Arrest (Cardiac Arrest) 03/2011 - 01/2009
3	Vascular Remodeling 08/2004 - 03/2003
2	Tachycardia (Tachyarrhythmias) 01/2015 - 06/2008
2	Hypertrophy 12/2014 - 09/2010
2	Vascular System Injuries 02/2010 - 11/2005
2	Insulin Resistance 01/2008 - 03/2007
1	Phenylketonurias (Phenylketonuria) 01/2021
1	Hypothermia 05/2016
1	Acute Coronary Syndrome 05/2016
1	Out-of-Hospital Cardiac Arrest 05/2016
1	Atrial Flutter (Flutter, Atrial) 01/2015
1	Aortic Valve Stenosis (Aortic Stenosis) 07/2014
1	Chronic Renal Insufficiency 08/2013
1	Glucose Intolerance 08/2013
1	Fibromuscular Dysplasia 08/2013
1	Cardiomyopathies (Cardiomyopathy) 08/2013
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2013
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 10/2010
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 09/2010
1	Embolism (Embolus) 09/2009
1	Infarction (Infarctions) 04/2009
1	Myositis (Idiopathic Inflammatory Myopathies) 03/2009

Drug/Important Bio-Agent (IBA)

16	Dobutamine FDA LinkGeneric 05/2015 - 01/2002
13	GadoliniumIBA 06/2014 - 01/2002
11	Adenosine (Adenocard)FDA LinkGeneric 03/2011 - 01/2002
7	FurinIBA 02/2013 - 03/2003
6	Gadolinium DTPA (Magnevist)FDA Link 01/2012 - 01/2003
6	IntegrinsIBA 03/2010 - 11/2002
5	tetrapeptide carbamateIBA 11/2005 - 03/2003
5	Proteins (Proteins, Gene)FDA Link 11/2005 - 03/2002
4	Clopidogrel (Plavix)FDA Link 05/2016 - 04/2002
4	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 01/2013 - 04/2005
4	Contrast MediaIBA 01/2012 - 06/2003
4	Phenobarbital (Luminal)FDA Link 01/2011 - 02/2002
3	Matrix Metalloproteinases (MMPs)IBA 01/2013 - 11/2005
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2009 - 02/2003
3	PPAR gammaIBA 01/2008 - 04/2003
3	Insulin (Novolin)FDA Link 01/2008 - 08/2003
2	Pharmaceutical PreparationsIBA 05/2016 - 01/2012
2	CollagenIBA 12/2014 - 08/2002
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 06/2013 - 04/2002
2	SubtilisinIBA 01/2013 - 04/2005
2	Fibronectins (Fibronectin)IBA 02/2012 - 08/2002
2	Apolipoproteins E (ApoE)IBA 02/2012 - 03/2008
2	gadofosveset trisodium (MS 325)FDA Link 01/2012 - 11/2007
2	Atropine FDA LinkGeneric 09/2010 - 10/2004
2	C-Reactive ProteinIBA 02/2010 - 08/2004
2	LigandsIBA 01/2008 - 12/2004
2	Coenzyme A (CoA)IBA 02/2006 - 02/2003
2	Matrix Metalloproteinase 14 (MT1-MMP)IBA 05/2005 - 08/2004
2	Integrin alphaVIBA 02/2004 - 03/2003
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2003 - 05/2002
2	Messenger RNA (mRNA)IBA 03/2003 - 08/2002
1	Amino Acids FDA Link 01/2021
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2021
1	P-SelectinIBA 06/2013
1	SelectinsIBA 06/2013
1	trkA ReceptorIBA 02/2013
1	Nerve Growth Factor (NGF)IBA 02/2013
1	InterleukinsIBA 02/2012
1	Interleukin-2 (IL2)IBA 02/2012
1	sudan IIIIBA 02/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2011
1	CD40 Ligand (CD40L)IBA 01/2011
1	Insulin-Like Growth Factor I (IGF-1)IBA 04/2010
1	Insulin-Like PeptidesIBA 04/2010
1	ElementsIBA 07/2009
1	Propofol (Diprivan)FDA LinkGeneric 06/2009

Therapy/Procedure

8	Therapeutics 05/2016 - 04/2002
4	Denervation 12/2014 - 08/2013
4	Percutaneous Coronary Intervention 06/2013 - 02/2004
4	Stents 01/2008 - 04/2003
3	Catheters 09/2014 - 12/2003
2	Radiofrequency Ablation 08/2013 - 06/2008
1	Sympathectomy (Sympathectomies) 08/2018
1	Cryosurgery 01/2015
1	Transcatheter Aortic Valve Replacement 07/2014
1	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 02/2012
1	Defibrillators (Defibrillator) 02/2012
1	Catheter Ablation 12/2009
1	Thrombolytic Therapy 09/2009